Department of Crystallography and Biophysics, University of Madras* Dept. of Organic Chemistry, University of Madras, Guindy Campus, Chennai - 600 025** Dept. of Crystallography and Biophysics, University of Madras, Guindy Campus, Chennai - 600 025***
○Palani kandavelu* Jaisankar P** Srinivasan P.C** Ponnuswamy M.N.***
Indole ring system is present in a number of natural products. The halogenated indole derivatives exhibit antibacterial activity against Gram-positive, Gram-negative bacteria and fungi. Indole derivatives also intercalate with DNA. To establish the structures, the following aldehye indole derivatives are studied by crystallographic methods.
1. 3-Chloro-1-phenylsulfonyl-1H-indole-2-carbaldehyde (CLPIC) crystallizes in triclinic space group P1 with cell parameters a = 8.048(2)Å, b = 9.568(3)Å, c = 9.931(3)Å, α= 79.433(4)ﾟ, β= 82.145(4)ﾟ, γ= 69.839(4)ﾟ, V = 703.4(4)Å3 , Z = 2 and refined to a final R-value of 0.0544.
2. 3-Cyano-1-phenylsulfonyl-1H-indole-2-carbaldehyde (CYPIC) crystallizes in triclinic space group P1 with cell parameters a = 9.554(2)Å, b = 12.193(3)Å, c = 13.637(3)Å, α= 103.199(4)ﾟ, β= 95.814(4)ﾟ, γ= 111.969(4)ﾟ, V = 1403.3(5) Å3, Z = 4 and refined to a final R-value of 0.0862.
In CYPIC, there are two crystallographically independent molecules in the asymmetric unit. The indole ring systems are planar, the dihedral angle formed by the pyrrole and benzo planes are 1.1(1)ﾟ in CLPIC and 0.5(2)ﾟ and 2.0(1)ﾟ for molecules A and B of CYPIC. The molecules stabilized by C-H…O, C-H…π and π…π types of interactions in addition to van der Waal's forces.