1. Life science
Our group promotes research in the field of life science using synchrotron radiation, for which we have developed state-of-the-art beamlines and experimental devices. We have expanded our research to link biopolymers to cells and tissues using X-ray crystal structural analysis, small-angle X-ray scattering, X-ray imaging, and X-ray cell irradiation.
In addition to the research by the department staff, our school promotes interuniversity research as one of the interuniversity research institutes. We also conduct research in cooperation with industry, academia, and the government in the fields of pharmacy, nutrition, and the environment, to name a few.
[Main research projects]
Elucidation of functions and mechanisms of nuclear proteins in eukaryotes
We are studying the intranuclear reactions in a cell, such as transcription and replication from a chromatin template, using the spatial structures of biopolymers such as proteins, DNA, and RNA. In particular, with a focus on the relationship between epigenetic information and intranuclear reactions, we are studying how the functions of individual molecules integrate to yield complex functions.
Elucidation of the causes of diseases determined from the structures of proteins related to infectious and other diseases
We are studying the causes of infection and diseases by studying the spatial structures of molecules (molecular complex) related to infectious and other diseases, and we aim to establish the foundation for the discovery of drugs to fight these diseases.
Elucidation of the mechanisms of enzyme reactions
We are studying the spatial structures of intermediate enzymes to elucidate the relationship between the spatial structures and the functions of enzymes that help chemical reactions in a living body.
Elucidation of the mechanism of intracellular and extracellular signaling and substance transportation
We are studying the structure of biopolymers (biopolymer complex) to elucidate the mechanisms of intracellular and extracellular signaling and substance transportation.
Elucidation of the mechanism of biological effects of radiation
We are studying the effects of radiation on cells, from the molecular level to the tissue level, by using the variable energy of synchrotron radiation and microbeams obtained from high-luminance light.
Development of a synchrotron radiation X-ray imaging system that can be applied to medical science
To obtain knowledge from imaging data about a living body and various diseases, we are developing an imaging system that utilizes the characteristics of synchrotron radiation, and conducting research into its application.
Development of advanced methods and devices for synchrotron radiation research in life science
We are upgrading to new analysis methods and beamlines, and developing multifaceted analysis methods by combining multiple methods. We will provide these methods for joint usage.
|SENDA, Toshiya||Professor||Structural biology|
|KATO, Ryuichi||Assoc.Professor||Structural biology|
|IGARASHI, Noriyuki||Assoc.Professor||Structural biology|
|KAWASAKI, Masato||Assoc.Professor||Structural biology|
|HYODO, Kazuyuki||Assoc.Professor||Medical imaging|
|SHIMIZU, Nobutaka||Assoc.Professor||Structural biology|
|MATSUGAKI, Naohiro||Assoc.Professor||Structural biology|
|YUMOTO, Fumiaki||Assoc.Professor||Structural biology|
|USAMI, Noriko||Assoc. Professor||Radiation biology|
|YAMADA, Yusuke||Assistant Professor||Structural biology|
|TOMITA, Ayana||Assistant Professor||Structural biology|
|ADACHI, Naruhiko||Assistant Professor||Structural biology|
|SENDA, Miki||Assistant Professor||Structural biology|
|SAIJO, Shinya||Assistant Professor||Structural biology|
[Beamlines in charge ]
BL-1A, BL-5A, BL-17A, NE-3A, NW-12A
Small-angle X-ray scattering of muscle and alloys
BL-6A, BL-10C, BL-15A2
X-ray imaging and multi-purpose experiments
BL-14C, (NE-5A), NE-7A
Radiation biology, soft X-ray photoelectron spectorscopy
Structural Biology Research Center http://pfweis.kek.jp/eng/index.html